Invention Grant
- Patent Title: Voltage-dependent t-type calcium channel blocker
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Application No.: US16069221Application Date: 2017-01-12
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Publication No.: US11420944B2Publication Date: 2022-08-23
- Inventor: Hiroto Tanaka , Isao Ooi , Yuzo Mogi , Masaaki Hirose , Tsuyoshi Endo , Toru Ogawa , Atsufumi Kawabata
- Applicant: Nippon Chemiphar Co., Ltd. , Kinki University
- Applicant Address: JP Tokyo; JP Osaka
- Assignee: Nippon Chemiphar Co., Ltd.,Kinki University
- Current Assignee: Nippon Chemiphar Co., Ltd.,Kinki University
- Current Assignee Address: JP Tokyo; JP Osaka
- Agency: Wood Herron & Evans LLP
- Priority: JPJP2016-003769 20160112
- International Application: PCT/JP2017/000898 WO 20170112
- International Announcement: WO2017/122754 WO 20170720
- Main IPC: C07D403/12
- IPC: C07D403/12 ; C07D407/12 ; C07D409/12 ; C07D409/14 ; C07D413/12 ; C07D417/12 ; C07D235/16 ; C07D413/14 ; C07D401/12 ; C07D405/12 ; C07D417/14 ; C07D471/04 ; C07D491/048 ; A61K31/4184 ; A61K31/4025 ; A61K31/428 ; A61K31/5377 ; A61K31/427 ; C07D333/32 ; A61K31/4245 ; A61K31/496 ; A61K31/381 ; A61K31/437 ; A61K31/423 ; A61K31/55 ; A61K31/343 ; A61K31/454 ; C07D307/81 ; A61K31/4355 ; A61K31/4709 ; A61P25/04

Abstract:
A compound represented by the following General Formula (I), a tautomer or a stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof, is used as a voltage-dependent T-type calcium channel blocker: wherein A represents a 5-membered heteroaryl group or a fused ring of a 5-membered or 6-membered heterocyclic ring with a benzene ring or a pyridine ring, each of which may have a substituent; R represents a hydrogen atom or the like; B represents CR5(Q1) or NQ2, herein Q1 represents a benzimidazole group which may have a substituent, or the like; Q2 represents an alkyl group having 1 to 8 carbon atoms which may have a substituent, a heteroaryl group which may have a substituent, or the like; R0, R1, R2, R3, R4, and R5 each represent a hydrogen atom or the like; and n and m each represent 0, 1, or 2.
Public/Granted literature
- US20190077767A1 VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL BLOCKER Public/Granted day:2019-03-14
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