Invention Grant
- Patent Title: Method for synthesizing amanitins
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Application No.: US16637361Application Date: 2018-08-06
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Publication No.: US11420971B2Publication Date: 2022-08-23
- Inventor: Werner Simon , Susanne Werner-Simon , Christian Lutz , Christoph Müller , Torsten Hechler , Michael Kulke
- Applicant: Heidelberg Pharma Research GmbH
- Applicant Address: DE Ladenburg
- Assignee: Heidelberg Pharma Research GmbH
- Current Assignee: Heidelberg Pharma Research GmbH
- Current Assignee Address: DE Ladenburg
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: EP17185181 20170807
- International Application: PCT/EP2018/071265 WO 20180806
- International Announcement: WO2019/030171 WO 20190214
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K47/68 ; C07K1/06 ; C07K7/64 ; A61P35/00
Abstract:
The invention relates to novel methods for synthesizing amanitin derivatives having an amino group attached to position 6′ of the central tryptophan moiety. The invention furthermore relates to a novel amanitin derivative having an amino group attached to position 6′ of the central tryptophan moiety, novel conjugates of such amanitin derivative, and pharmaceutical compositions comprising such conjugates.
Public/Granted literature
- US20210061805A1 NOVEL METHOD FOR SYNTHESIZING AMANITINS Public/Granted day:2021-03-04
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