Certain IHSs (Information Handling Systems) may utilize displays that are foldable. Foldable displays may utilize OLED (organic light-emitting diode) display technology, which is particularly susceptible to screen burn-in. Embodiments implement procedures for mitigation of screen burn-in of a foldable display. When folded, a foldable display is logically divided into screen portions based on the locations of the folds. Embodiments mitigate screen burn-in separately in each these screen portions that are created by folding the display. A gap may be displayed along the length of the folds of a folded display, thus separating the different screen portions. Embodiments may implement procedures for mitigating screen burn-in from displaying such a gap. Embodiments may also determine screen portions of a folded display that are actively in use and may implement procedures for mitigating screen burn-in in inactive portions of the folded display.