A method and an apparatus for time slot multiplexing, and a communication device. At least one multiplexing node group in a subnet of a TDMA communication system may be determined according to a connection relationship among all nodes in the subnet, where a shortest communication link between every two nodes in each multiplexing node group includes at least the preset quantity of nodes, the preset quantity of nodes includes the two nodes, and the preset quantity is no less than 4. For each multiplexing node group, a multiplexing time slot allocated to the multiplexing node group is determined, and each node in the multiplexing node group is controlled to transmit data in the multiplexing time slot. The time slots can be shared by the nodes in the multiplexing node group, and therefore multiple nodes can transmit data in the multiplexing time slot.