- Patent Title: Substituted bisphenyl butanoic ester derivatives as NEP inhibitors
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Application No.: US16854355Application Date: 2020-04-21
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Publication No.: US11426375B2Publication Date: 2022-08-30
- Inventor: Yongshuai Chai , Sven Erik Godtfredsen , Mark Kagan , Yugang Liu , Mahavir Prashad , Zhaoyin Wang , Saijie Zhu
- Applicant: NOVARTIS AG
- Applicant Address: CH Basel
- Assignee: NOVARTIS AG
- Current Assignee: NOVARTIS AG
- Current Assignee Address: CH Basel
- Agent Timothy P. O'Dea
- Main IPC: A61K31/235
- IPC: A61K31/235 ; A61K31/24 ; A61K31/41 ; A61K31/197 ; A61P9/00 ; A61K31/405 ; C07C229/36 ; C07C233/47 ; C07C279/14 ; C07D209/08

Abstract:
The present disclosure provides a compound of Formula (I); or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are defined herein. The disclosure also relates to a method for manufacturing the compounds of the disclosure, and its therapeutic uses. The present disclosure further provides pharmaceutical composition of the compounds of the disclosure and a combination of pharmacologically active agents and a compound of the disclosure.
Public/Granted literature
- US20200246295A1 SUBSTITUTED BISPHENYL BUTANOIC ESTER DERIVATIVES AS NEP INHIBITORS Public/Granted day:2020-08-06
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