Invention Grant
- Patent Title: SHP2 inhibitors and methods of use thereof
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Application No.: US16261819Application Date: 2019-01-30
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Publication No.: US11426422B2Publication Date: 2022-08-30
- Inventor: Hongtao Yu , Eunhee Choi
- Applicant: Research Development Foundation
- Applicant Address: US NV Carson City
- Assignee: Research Development Foundation
- Current Assignee: Research Development Foundation
- Current Assignee Address: US NV Carson City
- Agency: Parker Highlander PLLC
- Main IPC: A61K31/7088
- IPC: A61K31/7088 ; A61K9/127 ; A61K9/51 ; A61P5/50 ; C12N15/113 ; A61P35/00 ; A61P3/10 ; A61K31/497 ; A61K31/506 ; A61K31/53 ; A61K45/06 ; A61K47/20 ; A61K47/26 ; A61K47/38 ; A61K9/00
Abstract:
Provided are methods for the treatment of insulin resistance and insulin receptor diseases with SHP2 inhibitors, such as allosteric inhibitors of SHP2 and RNAi or siRNA that target SHP2 expression. Compositions and methods for delivery of SHP2 inhibitors, such as liver-targeting liposomes or nanoparticles, are also provided.
Public/Granted literature
- US20190231805A1 SHP2 INHIBITORS AND METHODS OF USE THEREOF Public/Granted day:2019-08-01
Information query
