A vehicle pillar structure is provided including a pillar outer, a pillar inner, a front join section, and a rear join section. The pillar outer and pillar inner includes a first open cross-section and a second open cross-section having an open cross-section profile opening toward a vehicle width direction inner side in cross-section sectioned perpendicular to an extension direction of the pillar outer and the pillar inner. The pillar inner is second open cross-section disposed inside the first open cross-section so as to form a closed cross-section together with the first open cross-section. At the front join section, front walls configuring vehicle front side walls of the first open cross-section of the pillar outer and the second open cross-section of the pillar inner are joined together. At the rear join section, vehicle rear side end portions of the pillar outer and the pillar inner are joined together.