- Patent Title: Compounds for treatment of cardiac arrhythmias and heart failure
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Application No.: US17042616Application Date: 2019-03-28
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Publication No.: US11427542B2Publication Date: 2022-08-30
- Inventor: Josephrajan Thainashmuthu , Martha Sibrian-Vazquez , Douglas Boatman
- Applicant: Elex Biotech, Inc.
- Applicant Address: US OR Portland
- Assignee: Elex Biotech, Inc.
- Current Assignee: Elex Biotech, Inc.
- Current Assignee Address: US OR Portland
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2019/024694 WO 20190328
- International Announcement: WO2019/191502 WO 20191003
- Main IPC: C07C211/49
- IPC: C07C211/49 ; C07C217/88 ; C07D213/74 ; A61P9/06 ; A61P9/04 ; C07C229/64 ; C07C309/24 ; C07D209/44 ; C07D215/12 ; C07D217/04 ; C07D231/56 ; C07D257/04 ; C07D271/06 ; C07D295/13
Abstract:
This disclosure concerns compounds and a method for modulating the activity of calcium ion channels, including Ca2+-induced (or Ca2+-activated) calcium release channels and conformationally coupled calcium release channels such as ryanodine receptors. Some of the compounds have a structure according to formula I, or a stereoisomer, tautomer, hydrate, solvate, prodrug, or pharmaceutically acceptable salt thereof.
Public/Granted literature
- US20210139429A1 COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS AND HEART FAILURE Public/Granted day:2021-05-13
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