Invention Grant
- Patent Title: Methods for isolating adeno-associated virus using a polydialkylammonium salt
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Application No.: US16303545Application Date: 2017-05-25
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Publication No.: US11427809B2Publication Date: 2022-08-30
- Inventor: Wenling Dong , Anandita Seth , Robert J. Milczarek , Francesca P. Vitelli
- Applicant: LONZA HOUSTON INC.
- Applicant Address: US TX Houston
- Assignee: LONZA HOUSTON INC.
- Current Assignee: LONZA HOUSTON INC.
- Current Assignee Address: US TX Houston
- Agency: Medler Ferro Woodhouse & Mills PLLC
- International Application: PCT/US2017/034389 WO 20170525
- International Announcement: WO2017/205573 WO 20171130
- Main IPC: C12N15/10
- IPC: C12N15/10 ; C12N15/11 ; C12N9/22 ; C12N15/85 ; C12N15/113 ; C12N7/00
Abstract:
The invention relates to methods of selectively purifying an adeno-associated virus (AAV) from an aqueous biomass using a flocculent. In embodiments, the flocculent is polydiallyldialkylammonium salt, e.g., polydiallyldimethvlammonium chloride (pDADMAC).
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