Invention Grant
- Patent Title: Human alpha-galactosidase variants
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Application No.: US16721102Application Date: 2019-12-19
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Publication No.: US11427813B2Publication Date: 2022-08-30
- Inventor: William Casey Hallows , Kristen Jean Vallieu , Nikki Dellas , Yu Zhu , Judy Victoria Antonio Viduya , Chinping Chng , Antoinette Sero , Gjalt W. Huisman , Rachel Cathleen Botham , Moulay Hicham Alaoui Ismaili
- Applicant: Codexis, Inc.
- Applicant Address: US CA Redwood City
- Assignee: Codexis, Inc.
- Current Assignee: Codexis, Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Codexis, Inc.
- Main IPC: C12N9/40
- IPC: C12N9/40 ; A61K38/47 ; C12N15/52 ; C12N15/85 ; A61K38/00
Abstract:
The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved thermostability, serum stability, improved cellular uptake, stability under both acidic (pH 7) conditions, reduced immunogenicity, and improved globotriaosylceramide removal from cells. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.
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