Invention Grant
- Patent Title: T cell balance gene expression, compositions of matters and methods of use thereof
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Application No.: US15687089Application Date: 2017-08-25
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Publication No.: US11427869B2Publication Date: 2022-08-30
- Inventor: Aviv Regev , Vijay K. Kuchroo , Jellert Gaublomme , Youjin Lee , Chao Wang , Nir Yosef , Hongkun Park , James Kaminski
- Applicant: THE BROAD INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Applicant Address: US MA Cambridge; US MA Cambridge; US MA Cambridge; US MA Boston; US CA Oakland
- Assignee: THE BROAD INSTITUTE, INC.,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,PRESIDENT AND FELLOWS OF HARVARD COLLEGE,THE BRIGHAM AND WOMEN'S HOSPITAL, INC.,THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Current Assignee: THE BROAD INSTITUTE, INC.,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,PRESIDENT AND FELLOWS OF HARVARD COLLEGE,THE BRIGHAM AND WOMEN'S HOSPITAL, INC.,THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Current Assignee Address: US MA Cambridge; US MA Cambridge; US MA Cambridge; US MA Boston; US CA Oakland
- Agency: Johnson, Marcou, Isaacs & Nix, LLC
- Agent F. Brent Nix, Esq.; Michael B. Scher, Esq.
- Main IPC: C12Q1/6883
- IPC: C12Q1/6883 ; C12Q1/6881 ; G01N33/50
Abstract:
This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.
Public/Granted literature
- US20170349950A1 T CELL BALANCE GENE EXPRESSION, COMPOSITIONS OF MATTERS AND METHODS OF USE THEREOF Public/Granted day:2017-12-07
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