Invention Grant
- Patent Title: Compositions and methods for treating age-related diabetes and related disorders
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Application No.: US16702870Application Date: 2019-12-04
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Publication No.: US11428697B2Publication Date: 2022-08-30
- Inventor: Sagar P. Bapat , Ye Zheng , Ronald Evans , Michael Downes , Annette R. Atkins , Ruth T. Yu
- Applicant: SALK INSTITUTE FOR BIOLOGICAL STUDIES
- Applicant Address: US CA La Jolla
- Assignee: SALK INSTITUTE FOR BIOLOGICAL STUDIES
- Current Assignee: SALK INSTITUTE FOR BIOLOGICAL STUDIES
- Current Assignee Address: US CA La Jolla
- Agency: Greenberg Traurig, LLP
- Agent Melissa Hunter-Ensor; Leslie Serunian
- Main IPC: A61K39/395
- IPC: A61K39/395 ; G01N33/68 ; G01N33/53 ; C12Q1/68 ; C12Q1/6883 ; C07K16/28 ; A61P3/10 ; A61K39/00
Abstract:
The invention features compositions and methods treating or preventing for age-related insulin resistance, type 2 diabetes and related disorders. The method involves depleting fTreg cells with an anti-ST2 antibody to decrease age-related fTreg accumulation and restore insulin sensitivity, thereby treating age-related insulin resistance, type 2 diabetes and related disorders.
Information query
