Systems and methods for facilitating communication between a Human Interface Device (HID) and a remote resource such as, for example, an application provided by a virtual desktop. Embodiments relate to using one or more Application Programming Interfaces (APIs) to translate messages over a communication (COM) port tunnel, launching a program within the same session assigned to the COM port tunnel, utilizing client-side encryption, and redirecting HID messages to an embedded browser that is accessible over a virtual desktop.