A method of configuring a hybrid, multi-cloud gateway configuration system for executing an application programming interface (API) may comprise receiving, via a network interface device of the API service control plane system, gateway operation policies in a first format for execution of an API at a first gateway type and a second gateway type, generating via one of a plurality of gateway type policy translators and transmitting to a gateway of the first gateway type, a first configuration file in a second format, instructing the gateway of the first gateway type to provision the API to meet the gateway operation policies, and generating via another one of the plurality of gateway type policy translators and transmitting to a gateway of the second gateway type, a second configuration file in a third format, instructing the gateway of the second gateway type to provision the API to meet the gateway operation policies.