Host I/O requests directed to a logical storage volume are initially processed by accessing physical pages of non-volatile data storage having a default page size. An indication of an optimal page size for the logical storage volume is received, and the size of the physical pages of non-volatile data storage accessed to process host I/O requests directed to the logical storage volume is changed from the default page size to the optimal page size for the logical storage volume. The default page size is changed to the optimal page size for the logical storage volume by changing a size of physical pages of non-volatile data storage indicated by a mapping structure that maps logical addresses in an address space the logical storage volume to corresponding physical pages of non-volatile data storage from the default page size to the optimal page size for the logical storage volume.