A method and for quantifying a three-dimensional medical image volume are provided. An embodiment of the method includes: providing a two-dimensional representation image based on the medical image volume; defining a region of interest in the two-dimensional representation image; generating a feature signature for the region of interest; defining a plurality of two-dimensional image patches in the medical image volume; calculating, for each of the image patches, a degree of similarity between the region of interest and the respective image patch on the basis of the feature signature; visualizing the degrees of similarities.