Provided are techniques for detecting contamination propagation and performing decontamination. In response to receiving a request to detect contaminants and perform decontamination, an entity is identified. Whether there are contaminants on the entity is detected using any combination of sensor data, one or more images, and one or more contamination propagation patterns. In response to determining that there are no contaminants, the entity is allowed to pass through an entry point. In response to determining that there are contaminants, one or more decontamination techniques are identified, decontamination of the entity is performed, using the one or more decontamination techniques, and, in response to determining that the decontamination has been successful, the entity is allowed to pass through the entry point.