A multi-path subsystem may include a first processing path, a second processing path, a mixed signal return path, and a calibration engine configured to: estimate and cancel a direct current (DC) offset of the mixed signal return path, estimate and cancel a DC offset between the first processing path and the second processing path, estimate and cancel a phase difference between the first processing path and a sum of the second processing path and the mixed signal return path, estimate and cancel a return path gain of the mixed signal return path, and track and correct for a gain difference between the first processing path and the second processing path.