A system is provided for publishing a disparate per-client live media output stream based on dynamic insertion of targeted non-programming content and customized programming content. The system generates a first programming schedule based on one or more live input stream manifests or one or more pre-encoded media asset manifests selected based on one or more parameters, associated indexed metadata, and first additional content. The first programming schedule defines locations and types of decision points defined by one or more content placement opportunities. Based on schedule of one or more pre-encoded media assets and insertion of decision points, the first programming schedule controls publish of pre-encoded media asset manifests as first disparate live media output stream manifest, which is published for first client device based on insertion of the one or more live input stream manifests or one or more pre-encoded media asset manifests, associated indexed metadata, and first additional content.