Systems and methods for predicting motion of a target using imaging are provided. In one aspect, a method includes receiving image data, acquired using an imaging system, corresponding to a region of interest (“ROI”) in a subject, and generating a set of reconstructed images from the image data. The method also includes processing the set of reconstructed images to obtain motion information associated with a target in the ROI, and applying the motion information in a motion prediction framework to estimate a predicted motion of the target. The method further includes generating a report based on the predicted motion estimated.