Invention Grant
- Patent Title: Biomaterial based on aligned fibers, arranged in a gradient interface, with mechanical reinforcement for tracheal regeneration and repair
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Application No.: US17517027Application Date: 2021-11-02
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Publication No.: US11432922B2Publication Date: 2022-09-06
- Inventor: Michael Detamore , Lindsey Ott , Robert Weatherly
- Applicant: The University of Kansas , The Children's Mercy Hospital
- Applicant Address: US KS Lawrence; US MO Kansas City
- Assignee: The University of Kansas,The Children's Mercy Hospital
- Current Assignee: The University of Kansas,The Children's Mercy Hospital
- Current Assignee Address: US KS Lawrence; US MO Kansas City
- Agency: DLA Piper LLP (US)
- Main IPC: A61F2/04
- IPC: A61F2/04 ; A61F2/06 ; A61F2/07 ; A61F2/20 ; A61L27/10 ; A61L27/34 ; A61L27/18 ; A61L27/14

Abstract:
An implant can include a plurality of polymeric fibers associated together into a fibrous body. The fibrous body is capable of being shaped to fit a tracheal defect and capable of being secured in place by suture or by bioadhesive. The fibrous body can have aligned fibers (e.g., circumferentially aligned) or unaligned fibers. The fibrous body can be electrospun. The fibrous body can have a first characteristic in a first gradient distribution across at least a portion of the fibrous body. The fibrous body can include one or more structural reinforcing members, such as ribbon structural reinforcing members, which can be embedded in the plurality of fibers. The fibrous body can include one or more structural reinforcing members bonded to the fibers with liquid polymer as an adhesive, the liquid polymer having a substantially similar composition of the fibers.
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