Formulations such as serums to treat skin discoloration via a multi-modal approach are provided in some embodiments. In several embodiments, the formulations are configured to allow select ingredients to work together to effectively brighten skin and treat hyperpigmentation. In several embodiments, the formulations comprise a first anti-melanin agent, such as a Bidens pilosa extract, a second anti-melanin agent, such as a Rheum rhaponticum extract, and an anti-inflammatory agent, such as a Vitamin E compound. In several embodiments, the formulation is provided as a topical formulation.