An isolation hood for respiratory treatment is disclosed. The isolation hood may include a head enclosure defining an interior volume configured to receive the head of a patient, and a neck seal configured to couple the head enclosure to a neck of the patient. The isolation hood may include an inlet port configured to be coupled to a distal end of a treatment source tube and to a first end of a treatment delivery tube, and an outlet port configured to be coupled to an inline particle filter configured to permit air to flow through the head enclosure. The neck seal and the inline particle filter are each configured to prevent viral/bacterial aerosolization outside the hood. The inlet and outlet ports may be attached to respiratory tubing and non-invasive ventilatory equipment to permit aerosol-generating procedures within the hood while preventing viral/bacterial aerosolization outside the hood.