A flexographic printing press for printing a substrate web comprises at least one printing unit and at least one central cylinder. A plurality of printing couples are arranged around the periphery of the at least one central cylinder. A horizontally aligned dryer unit, having at least one guide element, is arranged above the printing unit in a vertical direction. The at least one horizontally aligned dryer unit has at least two dryer sections with one dryer section being arranged separated from the next dryer section by at least one diverting assembly. The at least one flexographic printing press has at least one roll unwinder and at least one roll winder. The at least one roll unwinder and the at least one roll winder are arranged on opposite sides of the at least one central cylinder.