Invention Grant
- Patent Title: Inhibitors of SOX18 protein activity for treating angiogenesis-and/or lymphangiogenesis-related diseases
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Application No.: US16472882Application Date: 2017-12-21
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Publication No.: US11434190B2Publication Date: 2022-09-06
- Inventor: Mathias Francois , Johannes Zuegg , Jeroen Overman , Sreeman Kumar Mamidyala , Angela Aguslyarti Salim , Frank Roger Fontaine , Matthew Allister Cooper , Robert John Capon , Avril Alexis Barbara Robertson
- Applicant: The University of Queensland
- Assignee: The University of Queensland
- Current Assignee: The University of Queensland
- Agency: Patterson + Sheridan, LLP
- Priority: AUAU2016905362 20161223
- International Application: PCT/AU2017/051439 WO 20171221
- International Announcement: WO2018/112545 WO 20180628
- Main IPC: C07C63/66
- IPC: C07C63/66 ; C07C39/15 ; C07C43/215 ; C07C63/331 ; C07C233/65 ; A61P35/00
Abstract:
Disclosed are compounds of a formula provided herein that show efficacy in the inhibition of SOX18 protein activity, and in particular with respect to the ability of SOX18 to bind DNA and/or particular protein partners. Further, methods of treating angiogenesis- and/or lymphangiogenesis-related diseases, disorders or conditions, such as cancer metastasis and vascular cancers, are provided herein.
Public/Granted literature
- US20190337880A1 INHIBITORS OF SOX18 PROTEIN ACTIVITY FOR TREATING ANGIOGENESIS-AND/OR LYMPHANGIOGENESIS-RELATED DISEASES Public/Granted day:2019-11-07
Information query
