Invention Grant
- Patent Title: Enzymatic process for the preparation of Droxidopa
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Application No.: US17059594Application Date: 2019-06-07
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Publication No.: US11434197B2Publication Date: 2022-09-06
- Inventor: Stefano Fogal , Paolo Stabile , Pierluigi Padovan , Matteo De Poli , Angelo Restelli
- Applicant: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
- Applicant Address: IT Montecchio Maggiore
- Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
- Current Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
- Current Assignee Address: IT Montecchio Maggiore
- Agency: Lucas & Mercanti, LLP
- Priority: EP18179043 20180621
- International Application: PCT/EP2019/064979 WO 20190607
- International Announcement: WO2019/243087 WO 20191226
- Main IPC: C07C227/20
- IPC: C07C227/20 ; C12N9/04 ; C07C227/18 ; C07C271/22 ; C07C269/06 ; C12P13/04 ; C07C229/36
Abstract:
The present invention relates to a process for the preparation of Droxidopa by means of an improved enzymatic reduction of a compound of formula (II): (II), wherein R1, R2 is independent hydrogen, acetyl, R3 is hydrogen, a C1-C4 linear or branched alkyl group and R4 is hydrogen or an amine protecting group.
Public/Granted literature
- US20210163401A1 ENZYMATIC PROCESS FOR THE PREPARATION OF DROXIDOPA Public/Granted day:2021-06-03
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