- Patent Title: 8-hydroxyquinoline derivatives as diagnostic and therapeutic agents
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Application No.: US16997501Application Date: 2020-08-19
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Publication No.: US11434203B2Publication Date: 2022-09-06
- Inventor: Neil Vasdev , Huan Steven Liang
- Applicant: The General Hospital Corporation
- Applicant Address: US MA Boston
- Assignee: The General Hospital Corporation
- Current Assignee: The General Hospital Corporation
- Current Assignee Address: US MA Boston
- Agency: Fish & Richardson P.C.
- Main IPC: C07D215/28
- IPC: C07D215/28 ; C07D401/12 ; A61P35/00 ; A61K51/04 ; C07D215/26 ; A61K45/06 ; A61P25/28 ; C07B59/00

Abstract:
The present application provides compounds useful in methods of treating neurological disorders such as Alzheimer's disease, and cancer such as prostate cancer. Also provided herein are radiolabeled compounds useful for imaging techniques, and techniques for diagnosis and monitoring of treatment of neurological disorders and cancer. An exemplary radiolabeled compound provided herein is useful as a radiotracer for positron emission tomography or single-photon emission computed tomography. Methods for preparing radiolabeled compounds and methods for preparing unlabeled compounds are also provided.
Public/Granted literature
- US20210024468A1 8-HYDROXYQUINOLINE DERIVATIVES AS DIAGNOSTIC AND THERAPEUTIC AGENTS Public/Granted day:2021-01-28
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