Invention Grant
- Patent Title: Method for synthesizing valsartan
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Application No.: US17259292Application Date: 2018-07-17
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Publication No.: US11434210B2Publication Date: 2022-09-06
- Inventor: Xiaohui Zhou , Xiaoren Zhu , Yuanxun Zhu , Peng Dong , Peng Wang , Jinsheng Lin , Wenquan Zhu , Min Li
- Applicant: Zhejiang Huahai Pharmaceutical Co., Ltd
- Applicant Address: CN Taizhou
- Assignee: Zhejiang Huahai Pharmaceutical Co., Ltd
- Current Assignee: Zhejiang Huahai Pharmaceutical Co., Ltd
- Current Assignee Address: CN Taizhou
- Agency: Renner, Otto, Boisselle & Sklar, LLP
- Priority: CN201810771261.1 20180713
- International Application: PCT/CN2018/096006 WO 20180717
- International Announcement: WO2020/010643 WO 20200116
- Main IPC: C07D257/04
- IPC: C07D257/04

Abstract:
A method for synthesizing valsartan, comprising the steps of: synthesizing a valsartan methyl ester intermediate to obtain a reaction mixture of the valsartan methyl ester intermediate; diluting the reaction mixture by salt water or water, and then using a first extraction solvent to extract the valsartan methyl ester intermediate; adding alkali to an organic layer containing the valsartan methyl ester intermediate for hydrolyzing, removing the organic layer, regulating pH of a water layer to be acidic by using acid, using the first extraction solvent to extract, concentrating a part of solvent, or distilling the solvent to dryness, and then adding a new solvent; finally, crystallizing, filtering, and drying to obtain the valsartan.
Public/Granted literature
- US20210269408A1 METHOD FOR SYNTHESIZING VALSARTAN Public/Granted day:2021-09-02
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