Invention Grant
- Patent Title: Salt and polymorph of benzopyrimidinone compound and pharmaceutical composition and use thereof
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Application No.: US16736300Application Date: 2020-01-07
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Publication No.: US11434226B2Publication Date: 2022-09-06
- Inventor: Jingshan Shen , Yang He , Weiming Chen , Jianfeng Li , Guanghui Tian , Xudong Gong , Zhen Wang , Rongxia Zhang , Yongjian Liu , Hualiang Jiang
- Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES , SUZHOU VIGONVITA LIFE SCIENCES CO., LTD. , TOPHARMAN SHANGHAI CO., LTD.
- Applicant Address: CN Shanghai; CN Jiangsu; CN Shanghai
- Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES,SUZHOU VIGONVITA LIFE SCIENCES CO., LTD.,TOPHARMAN SHANGHAI CO., LTD.
- Current Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES,SUZHOU VIGONVITA LIFE SCIENCES CO., LTD.,TOPHARMAN SHANGHAI CO., LTD.
- Current Assignee Address: CN Shanghai; CN Jiangsu; CN Shanghai
- Agency: Reinhart Boerner Van Deuren P.C.
- Priority: CN201710551480.4 20170707
- Main IPC: C07D403/12
- IPC: C07D403/12 ; A61K45/06

Abstract:
The present disclosure relates to a salt of phenyl pyrimidinone compound, a polymorph thereof and a pharmaceutical composition comprising the same and a use thereof, particularly relates to the hydrochlorate of phenyl pyrimidinone compound of following formula (I-A) and a pharmaceutically acceptable polymorph, solvate, hydrate, co-crystal, anhydrous substance, or amorphous form thereof, a pharmaceutical composition and a pharmaceutical unit dosage comprising the same, the preparing method and use thereof.
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