- Patent Title: Broad spectrum antibacterial activity of novel bisbenzimidazoles targeting topoisomerase IA and the synergistic composition of bisbenzimidazole with efflux pump inhibitors against pathogenic bacteria
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Application No.: US16072018Application Date: 2017-01-20
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Publication No.: US11434227B2Publication Date: 2022-09-06
- Inventor: Devapriya Sinha , Vibha Tandon
- Applicant: Jawaharlal Nehru University (JNU) , Vibha Tandon
- Applicant Address: IN New Delhi; IN New Delhi
- Assignee: Jawaharlal Nehru University (JNU),Vibha Tandon
- Current Assignee: Jawaharlal Nehru University (JNU),Vibha Tandon
- Current Assignee Address: IN New Delhi; IN New Delhi
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- Priority: IN201611002627 20160123
- International Application: PCT/IN2017/000013 WO 20170120
- International Announcement: WO2017/125944 WO 20170727
- Main IPC: C07D403/14
- IPC: C07D403/14 ; A61K31/198 ; A61K31/4184 ; C07D235/20 ; A61P31/06 ; A61K31/277 ; A61K45/06 ; A61K38/00
Abstract:
The present invention relates to potent antibacterial activity of novel bisbenzimidazoles (SP12a and SP12b) against both Gram positive and Gram negative bacteria and a synergistic composition comprising Bisbenzimidazole (HN12b) in combination with Efflux pump inhibitors against most of the pathogenic bacterial strains.
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