Invention Grant
- Patent Title: Substituted imidazoles for the treatment of cancer
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Application No.: US16924157Application Date: 2020-07-08
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Publication No.: US11434231B2Publication Date: 2022-09-06
- Inventor: Xiaohong Tian , Jian Hui Wu , Qianhui Yi
- Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/McGILL UNIVERSITY
- Applicant Address: CA Montreal
- Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/McGILL UNIVERSITY
- Current Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/McGILL UNIVERSITY
- Current Assignee Address: CA Montreal
- Agency: Lavery, De Billy, LLP
- Agent Beatrice Ngatcha
- Main IPC: A61K31/4178
- IPC: A61K31/4178 ; C07D233/64 ; C07D413/12 ; C07D411/14 ; A61K31/422 ; C07D403/12 ; C07D263/32 ; A61K31/496 ; C07D413/04 ; A61K31/454 ; C07D413/14 ; C07D401/14 ; A61K31/5377 ; C07D401/06 ; C07D413/06 ; C07D401/12 ; A61K45/06
Abstract:
There are provided compounds, their preparation and their use in the treatment of KRAS-driven cancers. The compounds according to the invention (general formula Class III) disrupt dimerization of KRAS and are inhibitors of KRAS mutants such as KRAS G12D, KRAS G12V and KRAS 12C. Embodiments of the compounds according to the invention are selective inhibitors of KRAS mutants over the wild-type (WT) KRAS.
Public/Granted literature
- US20200339554A1 COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCERS AND OTHER MEDICAL CONDITIONS Public/Granted day:2020-10-29
Information query
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