Invention Grant
- Patent Title: Vascular endothelial growth factor antagonists
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Application No.: US16051062Application Date: 2018-07-31
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Publication No.: US11434268B2Publication Date: 2022-09-06
- Inventor: Donald P. Bottaro , Fabiola Cecchi
- Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
- Applicant Address: US MD Bethesda
- Assignee: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
- Current Assignee Address: US MD Bethesda
- Agency: McBee Moore & Vanik IP, LLC
- Main IPC: A61K38/18
- IPC: A61K38/18 ; C07K14/475 ; C07K14/52 ; C07K14/71
Abstract:
The present invention provides variant VEGF polypeptides which have been altered in their C-terminal heparin binding region to lower their heparin binding affinity. These variants have been found to act as receptor antagonists for VEGF receptors and antagonize angiogenesis. These variants are useful to treat diseases characterized by pathological angiogenesis.
Public/Granted literature
- US20190177382A1 VASCULAR ENDOTHELIAL GROWTH FACTOR ANTAGONISTS Public/Granted day:2019-06-13
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