Invention Grant
- Patent Title: Lipid-polymer based complexation and delivery of nucleic acids
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Application No.: US16849943Application Date: 2020-04-15
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Publication No.: US11434317B2Publication Date: 2022-09-06
- Inventor: Sankaran Thayumanavan , Kingshuk Dutta
- Applicant: University of Massachusetts
- Applicant Address: US MA Boston
- Assignee: University of Massachusetts
- Current Assignee: University of Massachusetts
- Current Assignee Address: US MA Boston
- Agency: Milstein Zhang & Wu LLC
- Main IPC: C08F299/04
- IPC: C08F299/04 ; C08F220/38 ; A61K47/58 ; A61K47/54 ; B82Y5/00
Abstract:
The invention provides novel polymers, crosslinked polymer-nucleic acid complexes, lipid-polymer-nucleic acid-based complexation and nanoassemblies, and nanoassembly-based intracellular delivery of nucleic acids and controlled release thereof upon degradation of the nanoassemblies in response to specific microenvironment in the cell, and compositions and methods of preparation and use thereof.
Public/Granted literature
- US20200332047A1 LIPID-POLYMER BASED COMPLEXATION AND DELIVERY OF NUCLEIC ACIDS Public/Granted day:2020-10-22
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