Invention Grant
- Patent Title: Agent for removing undifferentiated iPS cells
-
Application No.: US16471474Application Date: 2017-12-19
-
Publication No.: US11434472B2Publication Date: 2022-09-06
- Inventor: Yasushi Hiramine , Masayo Fujiwara , Hitoshi Ban , Futoshi Hasegawa
- Applicant: Sumitomo Pharma Co., Ltd.
- Applicant Address: JP Osaka
- Assignee: Sumitomo Pharma Co., Ltd.
- Current Assignee: Sumitomo Pharma Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Fish & Richardson P.C.
- Priority: JPJP2016-247139 20161220
- International Application: PCT/JP2017/045612 WO 20171219
- International Announcement: WO2018/117127 WO 20180628
- Main IPC: C12N5/074
- IPC: C12N5/074 ; A61K35/12 ; A61K31/4178 ; A61K31/422 ; A61K31/427 ; A61K31/4439 ; A61K31/5365 ; A61K31/4375 ; A61K31/4709 ; A61K31/4725 ; A61K31/497 ; A61K31/4174 ; A61K31/4365 ; C07D233/88 ; C07D401/12 ; C07D403/12 ; C07D413/12 ; C07D417/12 ; C07D471/04 ; C07D498/04

Abstract:
The present invention provides a compound of formula (1) or a salt thereof wherein ring Q1 is optionally-substituted C6-10 aryl, etc.; R1 and R2 are independently hydrogen atom, etc.; W1 is C1-4 alkylene which may be optionally substituted with 1 to 3 fluorine atoms or C3-7 cycloalkyl; W2 is —NR4aC(O)—, etc. wherein R4a is hydrogen atom or C1-6 alkyl; ring Q2 is optionally-substituted C6-10 aryl, etc., which has an inhibitory effect on the sphere-forming ability of cancer cells and is useful an agent for removing iPS cells.
Public/Granted literature
- US20190390172A1 AGENT FOR REMOVING UNDIFFERENTIATED iPS CELLS Public/Granted day:2019-12-26
Information query