Invention Grant
- Patent Title: Glucose oxidase GOD mutant and gene and application thereof
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Application No.: US15734568Application Date: 2018-12-20
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Publication No.: US11434473B2Publication Date: 2022-09-06
- Inventor: Bin Yao , Huiying Luo , Tao Tu , Huoqing Huang , Xiaoyun Su , Yaru Wang , Yingguo Bai , Yuan Wang , Kun Meng
- Applicant: INSTITUTE OF ANIMAL SCIENCE OF CHINESE ACADEMY OF AGRICULTURAL SCIENCES
- Applicant Address: CN Beijing
- Assignee: INSTITUTE OF ANIMAL SCIENCE OF CHINESE ACADEMY OF AGRICULTURAL SCIENCES
- Current Assignee: INSTITUTE OF ANIMAL SCIENCE OF CHINESE ACADEMY OF AGRICULTURAL SCIENCES
- Current Assignee Address: CN Beijing
- Agency: Patshegen IP
- Agent Moshe Pinchas
- Priority: CN201810561796.6 20180604
- International Application: PCT/CN2018/122270 WO 20181220
- International Announcement: WO2019/233083 WO 20191212
- Main IPC: C12N9/04
- IPC: C12N9/04
Abstract:
The present invention takes the glucose oxidase GOD from Aspergillus niger as the mutation template to obtain the glucose oxidase GOD mutants with improved catalytic efficiency and thermal stability by site directed mutagenesis. The specific activity of the mutant of the present invention is 66% higher than that of the wild type GOD; the enzyme activity of the mutant of the present invention is 13.6 times higher than that of the wild type after being treated at 70° C. for 10 min; and the enzyme activity of the mutant of the present invention is 29.4 times higher than that of the wild type after being treated at 80° C. for 2 min.
Public/Granted literature
- US20210230561A1 GLUCOSE OXIDASE GOD MUTANT AND GENE AND APPLICATION THEREOF Public/Granted day:2021-07-29
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