Invention Grant
- Patent Title: Methods for increasing mannose content of recombinant proteins
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Application No.: US17533004Application Date: 2021-11-22
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Publication No.: US11434514B2Publication Date: 2022-09-06
- Inventor: Chung-Jr Huang , Xiaoming Yang
- Applicant: Amgen Inc.
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Henry P. Wu
- Main IPC: C12P21/00
- IPC: C12P21/00 ; C12N5/00 ; C07K16/00
Abstract:
The present invention relates to methods of upregulating the high mannose glycoform content of a recombinant protein during a mammalian cell culture by manipulating the mannose to total hexose ratio in the cell culture media formulation.
Public/Granted literature
- US20220081700A1 METHODS FOR INCREASING MANNOSE CONTENT OF RECOMBINANT PROTEINS Public/Granted day:2022-03-17
Information query
