The catalyst deterioration detection system 1 comprises an air-fuel ratio detection device 41 detecting an air-fuel ratio of an exhaust gas flowing out from the catalyst 20, an air-fuel ratio control part 71, and a deterioration judgment part 72. The air-fuel ratio control part is configured to perform a lean control making the air-fuel ratio of the inflowing exhaust gas leaner than a stoichiometric air-fuel ratio and a rich control making the air-fuel ratio of the inflowing exhaust gas richer than the stoichiometric air-fuel ratio. The deterioration judgment part is configured to calculate an amplitude of an air-fuel ratio of an exhaust gas flowing out from the catalyst due to the lean control and the rich control based on an output of the air-fuel ratio detection device and judge that the catalyst is deteriorating if the amplitude is equal to or greater than a threshold value.