A diaphragm pump having a crankshaft that is rotatable about a rotational axis and coupled to a piston. The piston is reciprocally displaceable within a piston cylinder along an axis of motion between suction and discharge strokes. A diaphragm housing coupled to the piston cylinder at least partially defines a pumping chamber through which fluid is pumped as the piston reciprocates. The axis of motion, which intersects a connection between the piston and the connecting rod, may not intersect the rotational axis of the crankshaft such that, relative to an arrangement in which the axis of motion does intersect the rotational axis, a peak magnitude of piston side load forces during the discharge stroke is reduced and a peak magnitude of piston side load forces during the suction stroke is increased so as to attain an improved balance between the peak magnitudes of piston side load forces of the discharge and suction strokes.