A control knob lockout device for rendering knobs of a stove inoperable includes a pair of latches, a pair of keepers, and a housing. The latches are mountable to a stove so that the latches are positioned singly proximate to opposed sides of the stove. The latches also are positioned in substantial alignment with a set of control knobs that is engaged to a surface of the stove. The housing defines an interior space and has a rear face. The rear face has an opening positioned therein to insert the set of control knobs so that the housing is positioned thereover. The pair of keepers is engaged to a front face of the housing. Each keeper is positioned proximate to a respective opposed end of the housing and selectively engages a respective latch to fixedly position the housing over the set of control knobs.