Invention Grant
- Patent Title: CD127 expression inversely correlates with FoxP3 and suppressive function of CD4+ Tregs
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Application No.: US15958638Application Date: 2018-04-20
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Publication No.: US11435349B2Publication Date: 2022-09-06
- Inventor: Jeffrey A. Bluestone , Weihong Liu , Amy Putnam
- Applicant: The Regents of the University of California
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Kilpatrick Townsend & Stockton LLP
- Main IPC: C12N5/0783
- IPC: C12N5/0783 ; G01N33/569 ; A61K39/00 ; G01N33/50 ; A61K35/17 ; A61K35/12
Abstract:
The invention provides methods of isolating CD127lo/− immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding the isolated cells, pharmaceutical compositions of such cells, and methods of their use in the treatment of autoimmune and other immune system mediated disorders.
Public/Granted literature
- US20180238880A1 CD127 EXPRESSION INVERSELY CORRELATES WITH FOXP3 AND SUPPRESSIVE FUNCTION OF CD4+ TREGS Public/Granted day:2018-08-23
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