In accordance with an embodiment, described herein is a system and method for enabling advertisement interaction with an electronic device, for use in a digital media content environment. A media device includes a touch-sensitive display screen, and user interface that enables access to a stored media application. During the streaming of media content from a media server, an audio advertisement or other type of advertisement can be inserted into a stream, for playback at the media device. Using playback controls provided either by the user interface, or by a headphones, headset, or other type of device, a user can interact with the advertisement (even if the user interface is locked), by performing a defined gesture, which, if received at the media application during a defined time period associated with the advertisement, is interpreted as a signal to select or otherwise interact with the advertisement.