Systems, methods and apparatus of predictive management of failing portions of data storage media in a data storage device. For example, the data storage device can include: one or more storage media components; a controller configured to store data into, and retrieve data from, a portion of the one or more storage media components; and an artificial neural network configured to receive, as input from the controller, parameters relevant to health of the portion and generate an anomaly classification based on the input. The controller can be configured to adjust a data storage usage of the portion in response to the anomaly classification. For example, the controller can improve data reliability operations to reduce the likelihood of data loss and/or catastrophic failure.