Traffic data is divided into data streams corresponding to workloads, and the data streams are multiplexed onto slice segments based on a multiplexing requirement or rule. Each slice segment is a physical or virtual processing element in a wireless network supporting network slicing. In one example, the data streams are multiplexed onto the slice segments such that data streams having different utility definitions are assigned to different slice segments. In another example, the data streams are multiplexed onto the slice segments such that workloads in the same cluster partitioned in a T-dimensional vector space are assigned to different slice segments.