A comfort-based self-driving planning method is provided, including the steps of: a) establishing a relationship model of vibration road surface quality and driving comfort on the basis of a vehicle type; b) obtaining road ahead condition parameters, including abnormal condition information, road flatness and road surface anti-slide performance; c) obtaining the road ahead condition parameters, and adjusting a vehicle expected driving trajectory; d) respectively designing vehicle acceleration, deceleration and constant speed processes, and generating a speed change curve; and e) optimizing the speed change curve. Based upon changeable road surface quality and vehicle vibration action mechanism analysis and image-based road surface anti-slide coefficient evaluation technology, a GIS and vehicle-road communication technology are used to acquire road condition parameters, and vehicle acceleration, deceleration and constant speed processes are respectively designed on the basis of changes in the parameters.