The present invention relates to an organosilicon synthetic leather and a preparation method thereof. The organosilicon synthetic leather comprises a surface glue layer, a bottom glue layer, and a base layer which are overlapped sequentially. The preparation method comprises the steps of: mixing the main raw materials of the surface glue layer in a proper proportion to obtain a surface glue; mixing the main raw materials of the bottom glue layer in a proper proportion to obtain a bottom glue; coating and curing the surface glue on a release paper, coating the bottom glue on the cured surface glue to form the bottom glue layer, then compositing the bottom glue layer with the base layer and curing composited bottom glue layer, and striping the release paper to obtain the organosilicon synthetic leather. The inventive organosilicon synthetic leather has excellent safety, wear resistance, antifouling property and flame retardancy.