A two-stage turbocharged internal combustion engine comprises a low-pressure stage turbocharger mounted at a first end side of an engine block and a high-pressure stage turbocharger mounted at the same first end side of the engine block. The respective turbochargers are mounted via a mounting structure, Which also accommodates the charge air coolers associated with the turbochargers. In order to obtain a compact arrangement and reduce a length of pipe connections between the different components, the different charge air coolers are mounted to mounting structure such that they overlap in a plan view of the internal combustion engine. Further, flow directions of charge air in the different charge air coolers are opposite to each other.