Systems and methods for gesture-based control are provided. In some embodiments, a system may include a wearable device configured to be worn on a person's wrist. The wearable device may include a plurality of biopotential channels, a location sensor, and a processor. The system may be configured to generate a data stream based on the outputs from the biopotential channels and/or the location sensor. The system may be configured to enter a first state in which the output from the location sensor is processed according to a first set of logical rules. The system may be configured to classify a gesture, and, based on the gesture classification, transition to a second state in which the output from the location sensor is processed according to a second set of logical rules that is different than the first set of logical rules.