An information handling system executing a multimedia multi-user collaboration application (MMCA) may include a memory; a power management unit; a video camera to capture video of a user participating in a video conference session conducted by a processor executing code instructions of the MMCA via a first network link on a network interface device; a time-of-flight (TOF) sensor to provide distance data descriptive of the distance between a user's body and the video camera; the processor configured to execute a video frame user presence detection system to: slice a video frame into a plurality of video frame slices; based on the distance data, create a human object presence (HOP) heat map to assign a probability of the presence of the user's body within each video frame slice of the video frame; the processor configured to select, among the plurality of video frame slices, those video frame slices with an assigned probability of presence of the user's body that exceeds a threshold probability as a HOP video frame slice group where the user's body appears within the video frame; and the network interface device configured to send data defining the HOP video frame slice group to a sink information handling system participating in the video conference session over the network to assist decoding of the video frame at the sink information handling system.