A method for providing an optimum subtraction data set includes: receiving first image data sets acquired by a medical imaging device and which map an object under examination within a first time phase; receiving at least one second image data set acquired by the same or another medical imaging device and which maps a change in the object under examination within a second time phase; dividing the at least one second image data set into a plurality of image regions; generating subtraction image regions for the plurality of image regions; determining an image quality parameter for each subtraction image region; determining an optimum subtraction image region for each image region of the plurality of image regions of the at least one second image data set by comparing the image quality parameters; generating the optimum subtraction data set from the optimum subtraction image regions; and providing the optimum subtraction data set.