The disclosed systems and methods monitor power distribution systems for autonomous and drive-by-wire vehicles. The system can monitor input voltage, current, and other power signals, and reporting the input voltages and currents to a diagnostic engine control unit (ECU). The ECU compares the power signals with real-time (or substantially real-time) waveforms associated with vibrations, acceleration, road bumps, and other phenomena normally encountered in on-road operation, and evaluates any determined correlation between inertial events (e.g., bumps or acceleration, etc.) and changes in the power signals. If the diagnostic ECU determines a correlation between the inertial waveform, the diagnostic ECU map perform mitigating steps, such as issuing a vehicle health warning, generate instructions that cause the vehicle to navigate to a service center, or perform other mitigating actions.